Previously, the oneworld alliance member served Perth from its Doha hub with Boeing 777-300ERs.
The change to the A380, which is configured with eight first, 48 business and 461 economy seats for a total of 517 seats, represents a 44 per cent lift in capacity for Qatar Airways to Perth.
It also means Qatar will offer passengers a first class option to and from Perth, given the 777-300ER has a two-class layout spread across business and economy.
“Our Australia footprint has grown tremendously in the last two years, bearing testament to the country’s robust travel demand,” Qatar Airways senior manager for Australasia, Adam Radwanski, said.
Perth is now Qatar Airways’ third gateway in Australia served with the A380, behind Sydney and Melbourne. Qatar Airways also flies the A350-900 daily to Adelaide and the 777-300ER to Canberra.
Fellow Gulf carrier Emirates Airline was the first carrier to deploy the A380 to Perth in May 2015.
Qatar Airways Perth-Doha schedule
Perth-Doha QR901 Departs 23:05hrs, Arrives 05:40hrs+1
Doha-Perth QR900 Departs 02:05hrs, Arrives 18:25hrs